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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0973-3922
Vol. 73, No. 2, 2007, pp. 94-96
Bioline Code: dv07031
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 73, No. 2, 2007, pp. 94-96

 en Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris
Iraji, Fariba; Sadeghinia, Ali; Shahmoradi, Zabiholah; Siadat, Amir Hossein & Jooya, Abolfazl

Abstract

Background: Twenty percent azelaic acid gel is recommended as a topical treatment for acne due to its favorable profile.
Aim: Our objective in this study was to evaluate the efficacy of 20% azelaic acid gel in the treatment of mild to moderate acne vulgaris.
Methods: This was a double blind, randomized clinical trial. Sixty patients with mild to moderate acne vulgaris were selected randomly to receive either azelaic acid gel or the vehicle gel alone. Patients were followed up every 15 days for a period of 45 days. The number of lesions and the acne severity index (ASI) were recorded and compared using Student's t-test.
Results: Total lesion count was reduced by 60.6% and 19.9% by azelaic acid gel and the placebo respectively (P =0.002). ASI was reduced by 65.2% and 21.3% by azelaic acid gel and the placebo respectively (P =0.001), i.e., azelaic acid gel was 3.06 times more effective than the placebo in reducing ASI.
Conclusion: Azelaic acid gel can be used as an effective treatment in mild to moderate acne vulgaris.

Keywords
Acne, Azelaic acid gel, Topical treatment

 
© Copyright 2007 Indian Journal of Dermatology, Venereology and Leprology.
Alternative site location: http://www.ijdvl.com

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