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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 73, No. 4, 2007, pp. 280
Bioline Code: dv07105
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 73, No. 4, 2007, pp. 280

 en Net Study - Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study
Negi, Ajeet K.; Sharma, Nand Lal; Mahajan, Vikram K.; Ranjan, Nitin & Kanga, Anil K.

Abstract

Background: Intralesional sodium stibogluconate (SSG) has become first line therapy for localized cutaneous leishmaniasis (LCL).
Aims: This study compares the efficacy of intralesional SSG given alone with that of intralesional SSG combined with intramuscular SSG.
Methods: Thirty-two patients aged between 5-56 years were included in the study. The first group received three injections of intralesional SSG on alternate days while the other group received three injections of intralesional SSG similar to the first group and the rest of the calculated dose as a simultaneous, intramuscular injection. Patients were followed up every four weeks to assess for cure/ the need for repeating the treatment.
Results: Five patients from group 1 having small nodular lesions of < six months duration were cured after 1-2 treatment cycles. However, six patients with mucosal lesions, large lesions and lesions of > six months duration needed 3-5 treatment schedules. Most plaques and mucosal lesions in seven patients in group 2 cleared with two treatment cycles.
Conclusion: Intralesional combined with intramuscular SSG appears more effective in LCL and gave qualitatively superior healing than intralesional SSG given alone

Keywords
Localized cutaneous leishmaniasis, Intralesional sodium stibogluconate, Intramuscular sodium stibogluconate

 
© Copyright 2007 Indian Journal of Dermatology, Venereology and Leprology.
Alternative site location: http://www.ijdvl.com

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