Net Case - Angiolymphoid hyperplasia with eosinophilia associated with hepatitis C antibodies

Angiolymphoid hyperplasia, for a long time, has been confused with Kimura′s disease. In the recent past, various workers have tried to differentiate these two entities. Various new differences in immunohistochemistry have been found, which have not yet been included in the dermatology literature. In this case report, we have presented a middle-aged man complaining of recurrent nodular lesions on the right ear for 8 years. On examination there were multiple firm 0.5-2.0 cm size, erythematous to violaceous nodules located in and around the right ear. Regional lymph nodes were not involved, and there were no systemic complaints. Histopathological examination from the excision biopsy of one of the nodules revealed features classical of angiolymphoid hyperplasia with eosinophilia. Immunohistochemical stains carried out on the biopsy specimen revealed predominantly T-cell type of infiltrate. All routine investigations were within normal limits, and serum immunoglobulin E was marginally raised. He had positive anti-hepatitis C virus antibodies, an association not so far reported in the literature.

Keywords
Angiolymphoid hyperplasia with eosinophilia, Anti-hepatitis C virus antibodies, Immunohistochemistry, Kimura′s disease