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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 74, No. 4, 2008, pp. 364-366
Bioline Code: dv08158
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 74, No. 4, 2008, pp. 364-366

 en Multiple capillary hemangiomas: A distinctive lesion of multicentric Castleman's disease and POEMS syndrome
Misri, Rachita; Kharkar, Vidya; Dandale, Ameet; Patel, Vidula; Mahajan, Sunanda & Khopkar, Uday


A diagnosed case of Castleman′s disease, proven by biopsy from enlarged inguinal lymph nodes, presented with multiple, asymptomatic, erythematous papules and nodules prevalent since nine years over the trunk and extremities. The lesions had been gradually increasing in number and size. The patient had had plasmacytoma of the lower thoracic vertebra 12 years ago, for which he was adequately treated with chemotherapy and local radiotherapy. Dermatological examination revealed erythematous papules and nodules on the face, trunk, and extremities that were diagnostic of capillary hemangiomas. Histopathology of the erythematous, soft papule was suggestive of capillary hemangioma. Contrast-enhanced computerized tomography of the abdomen and pelvis showed multiple retroperitoneal nodes suggestive of Castleman′s disease along with multiple osteolytic lesions in the pelvic girdle and vertebrae. The patient was treated with injection rituximab and is currently under follow-up. We report this case to highlight a rare association between Castleman′s disease and POEMS syndrome.

Capillary hemangiomas, Castleman′s disease, POEMS syndrome, Vascular endothelial growth factor

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