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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 75, No. 5, 2009, pp. 492-494
Bioline Code: dv09155
Full paper language: English
Document type: Report
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 75, No. 5, 2009, pp. 492-494

 en Evaluation of ID-PaGIA syphilis antibody test
Naaber, Paul; Makoid, Ene; Aus, Anneli; Lõivukene, Krista & Põder, Airi

Abstract

Background: Laboratory diagnosis of syphilis is usually accomplished by serology. There are currently a large number of different commercial treponemal tests available that vary in format, sensitivity and specificity.
Aim: To evaluate the ID-PaGIA Syphilis Antibody Test as an alternative to other specific treponemal tests for primary screening or confirmation of diagnosis.
Methods: Serum samples from healthy adults (n = 100) were used for detection of specificity of ID-PaGIA. To evaluate sensitivity of ID-PaGIA serum samples (n = 101) from patients with confirmed or suspected syphilis were tested for syphilis antibodies with FTA-Abs IgM, ID-PaGIA, ELISA IgM and TPHA tests.
Results: No false-positive results were found with ID-PaGIA. Sensitivity of various treponemal tests was the following: FTA-Abs IgM: 95.5%, ID-PaGIA and ELISA IgM: 94%, and TPHA 75%. The positive and negative predictive values of ID-PaGIA were 100 and 89.5%, respectively. Conclusions: Compared with other treponemal tests ID-PaGIA has excellent sensitivity and specificity.

Keywords
Syphilis, Treponemal test, Rapid diagnostics

 
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Alternative site location: http://www.ijdvl.com

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