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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 75, No. 5, 2009, pp. 503-505
Bioline Code: dv09158
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 75, No. 5, 2009, pp. 503-505

 en Sister Mary Joseph's nodule: A case of umbilical cutaneous metastasis with signet ring cell histology
Zadeh, Valid Bagher; Kadyan, Randhir; Al-Abdulrazzaq, Adel; Al-Otaibi, Sultan; Sarhan, Amr & Najem, Nabeel


The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph′s nodule". It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer. We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area. Histopathological examination demonstrated diastase-resistant periodic acid-Schiff and mucicarmine positive signet ring cells, suggesting gastric carcinoma. Immunohistochemical staining showed that these cells were positive for cytokeratins and epithelial membrane antigen, suggesting epithelial origin.

Cutaneous metastasis, Sister Mary Joseph′s nodule, Signet ring cell

© Copyright 2009 Indian Journal of Dermatology, Venereology and Leprology.
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