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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 77, No. 2, 2011, pp. 177-179
Bioline Code: dv11048
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 77, No. 2, 2011, pp. 177-179

 en Vulvar ulcer as a presentation of systemic langerhans cell histiocytosis
Madnani, Nina A. & Khan, Kaleem J.

Abstract

We report a 38-year-old housewife with systemic Langerhans cell histiocytosis (LCH) presenting as a chronic vulvar and peri-anal ulcer. She had systemic involvement in the form of diabetes insipidus and bone "hot-spots". She responded favorably to etoposide, 6-mercaptopurine, and systemic steroids, and has been in remission since 10 years. Chronic vulvar ulcers not responding to routine therapy should not be neglected and need to be biopsied repeatedly to come to a specific diagnosis. The vulvar ulcer in our case provided a vital clue to a systemic LCH, with a successful outcome.

Keywords
Langerhans cell histiocytosis, vulvar ulcer, diabetes insipidus, etoposide

 
© Copyright 2011 Indian Journal of Dermatology, Venereology, and Leprology.
Alternative site location: http://www.ijdvl.com

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