Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
Vol. 77, No. 2, 2011, pp. 177-179
Bioline Code: dv11048
Full paper language: English
Document type: Case Report
Document available free of charge
Indian Journal of Dermatology, Venereology and Leprology, Vol. 77, No. 2, 2011, pp. 177-179
© Copyright 2011 Indian Journal of Dermatology, Venereology, and Leprology.
Vulvar ulcer as a presentation of systemic langerhans cell histiocytosis|
Madnani, Nina A. & Khan, Kaleem J.
We report a 38-year-old housewife with systemic Langerhans cell histiocytosis (LCH) presenting as a chronic vulvar and peri-anal ulcer. She had systemic involvement in the form of diabetes insipidus and bone "hot-spots". She responded favorably to etoposide, 6-mercaptopurine, and systemic steroids, and has been in remission since 10 years. Chronic vulvar ulcers not responding to routine therapy should not be neglected and need to be biopsied repeatedly to come to a specific diagnosis. The vulvar ulcer in our case provided a vital clue to a systemic LCH, with a successful outcome.
Langerhans cell histiocytosis, vulvar ulcer, diabetes insipidus, etoposide
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