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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0378-6323
Vol. 78, No. 1, 2012, pp. 19-23
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Bioline Code: dv12005
Full paper language: English
Document type: Symposium
Document available free of charge
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Indian Journal of Dermatology, Venereology and Leprology, Vol. 78, No. 1, 2012, pp. 19-23
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Melanocytorrhagy and apoptosis in vitiligo: Connecting jigsaw pieces
Kumar, Ravinder & Parsad, Davinder
Abstract
Vitiligo is an acquired depigmenting disorder characterized by a chronic and progressive loss of melanocytes from the epidermis and follicular reservoir. The mechanism of melanocyte disappearance has never been clearly understood. This review discussed the data supporting the theory of melanocytorrhagy and apoptosis as one of the primary defects underlying melanocyte loss. Theory of melanocytorrhagy proposes that non-segmental vitiligo is a primary melanocytorrhagic disorder with altered melanocyte responses to friction and possibly other types of stress, inducing their detachment and subsequent transepidermal loss. Melanocytes detachment induces apoptosis whereas adherence to basement membrane suppresses apoptosis. The study of apoptosis, mechanisms of its induction, and the ways to block apoptosis is one possible way to find both the causes of depigmentation and medications to prevent its progression.
Keywords
Apoptosis, melanocytorrhagy, pathogenesis, vitiligo
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© Copyright 2012 Indian Journal of Dermatology, Venereology, and Leprology. Alternative site location: http://www.ijdvl.com
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