Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
Vol. 6, No. 1, 2003, pp. 76-79
Bioline Code: ej03010
Full paper language: English
Document type: Short Communication
Document available free of charge
Electronic Journal of Biotechnology, Vol. 6, No. 1, 2003, pp. 76-79
© Copyright 2003 by Universidad Católica de Valparaíso -- Chile
Normalization of elevated liver enzymes due to V-1 Immunitor therapy|
Jirathitikal, Vichai; Metadilogkul, Orapun & Bourinbaiar, Aldar S.
V-1 Immunitor (V1) is an oral AIDS vaccine currently being used as a therapeutic modality by HIV-positive patients. Upon interim analysis of phase I safety trial it has been discovered that patients who had elevated liver enzymes aspartate (AST/SGOT) and alanine (ALT/SGPT) aminotransferases have experienced the reduction of enzyme levels back to normal. Two other hepatitis markers alkaline phosphatase and bilirubin have also decreased. V1's effect may be hepatitis-specific since liver enzymes in normal patients treated with V1 have not changed and three patients who were Hepatitis B antigen positive at baseline became negative after therapy. The results suggest that V1 supplementation reduces hepatic damage caused by hepatitis viral infection.
AIDS, hepatitis, oral, therapeutic, transaminase, vaccine
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