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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 10, No. 2, 2007, pp. 230-239
Bioline Code: ej07023
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 10, No. 2, 2007, pp. 230-239

 en Influence of medium constituents on the biosynthesis of cephalosporin-C
Nigam, Vinod Kumar; Verma, Ruchi; Kumar, Abhishek; Kundu, Subir & Ghosh, Purnendu


Acremonium chrysogenum NCIM 1069 was used for the biosynthesis of cephalosporin-C (CPC) in batch mode of cultivation. The effect of different medium constituents for better yield of CPC was thoroughly investigated. From the results of the fermentation, it was found that ammonium sulphate as inorganic nitrogen source and methionine at the concentration of 0.4% are most suitable for higher yield of antibiotic. The variation in the C/N ratio on the biosynthesis of CPC showed that a C/N ratio of 8.0 is most suitable for maximum production of CPC.

Acremonium chrysogenum, batch fermentation, cephalosporin-C, methionine, stirred tank bioreactor.

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