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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 16, No. 1, 2013, pp. 1-10
Bioline Code: ej13003
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 16, No. 1, 2013, pp. 1-10

 en Evaluation of antimicrobial activity and cell viability of Aloe vera check for this species in other resources sponges
de Lacerda Gontijo, Sávio Morato; Gomes, Alinne Damásia Martins; Gala-García, Alfonso; Sinisterra, Rubén Dario & Cortés, Maria Esperanza

Abstract

Background: Aloe vera check for this species in other resources L., member of the Liliaceae family, has been shown to stimulate cell proliferation and contribute to healing and angiogenesis, has anti-bacterial, anti-fungal and antiinflammatory activity. In addition, Aloe vera can be used as a support for drug transport. Our objective is to evaluate antimicrobial activity and cytotoxicity of sponges of Aloe vera L. for use as a carrying support of drugs.
Results: In this work, sponge of free Aloe vera (AV) loaded with amoxicillin (AMX) or nystatin (NYS) at 1% w/w, were prepared and physico-chemically characterized via X-ray diffraction, Fourier Transform Infrared Spectroscopy and thermal analysis. Antimicrobial potency of AV sponge alone, loaded with AMX or NYS, against strains of Streptococcus mutans check for this species in other resources , Staphylococcus aureus check for this species in other resources , Aggregatibacter actinomycetemcomitans check for this species in other resources , Enterococcus faecalis check for this species in other resources and Candida albicans check for this species in other resources was determined. Osteoblasts and human gingival fibroblasts were cultivated on AV, Aloe vera loaded with amoxicillin (AV/AMX) and Aloe vera loaded with nystatin (AV/NYS) and cellular viability was assessed. The physico-chemical characterization performed suggested that the loaded drugs were dispersed in the sponge and those interactions between the AV sponge and the loaded drugs were weak. Furthermore, AV loaded with AMX or NYS demonstrated antimicrobial potency and osteoblasts and fibroblasts were viable after 24 hrs on free AV, and AV loaded with AMX or NYS.
Conclusions: Our results indicate that sponges of free AV, loaded with AMX or NYS, are biocompatible and exhibit antimicrobial activity.

Keywords
amoxicillin; cytotoxicity; drug transport; nystatin

 
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