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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 16, No. 4, 2014
Bioline Code: ej13031
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 16, No. 4, 2014

 en Analysis of batch and repeated fedbatch productions of Candida utilis check for this species in other resources cell mass using mathematical modeling method
Lin, Yutian; Liu, Guoli; Lin, Huibin; Gao, Ling & Lin, Jianqiang


Background: Candida utilis check for this species in other resources is widely used in bioindustry, and its cell mass needs to be produced in a cost effective way. Process optimization based on the experimental results is the major way to reduce the production cost. However, this process is expensive, time consuming and labor intensive. Mathematical modeling is a useful tool for process analysis and optimization. Furthermore, sufficient information can be obtained with fewer experiments by using the mathematical modeling, and some results can be predicted even without doing experiments.
Results: In the present study, we performed the mathematical modeling and simulation for the cell mass production of Candida utilis based on limited batch and repeated fedbatch experiments. The model parameters were optimized using genetic algorithm (GA), and the processes were analyzed.
Conclusions: Taken together, this newly developed method is efficient, labor saving and cost effective.

Candida utilis; fermentation; genetic algorithm; mathematical model

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