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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 16, No. 4, 2013
Bioline Code: ej13044
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 16, No. 4, 2013

 en Modeling of glutamic acid production by Lactobacillus plantarum check for this species in other resources MNZ
Zareian, Mohsen; Ebrahimpour, Afshin; Mohamed, Abdul Karim Sabo & Saari, Nazamid

Abstract

Background: L-glutamic acid, the principal excitatory neurotransmitter in the brain and an important intermediate in metabolism acts as a precursor of γ-amino butyric acid (GABA). In the present study, culture condition for enhanced glutamic acid production by Lactobacillus plantarum check for this species in other resources MNZ was optimized and the influence of such conditions on GABA production was evaluated.
Results: Results indicated that glutamic acid increased up to 3-fold (3.35) under the following condition: pH 4.5, temperature 37°C, 12% (w/v) glucose and 0.7% (w/v) ammonium nitrate; whilst GABA production was enhanced up to 10-fold under the following condition: pH 4.5, temperature 37oC, 6% (w/v) glucose and 0.7% (w/v) ammonium nitrate.
Conclusions: This is the first report for dual biosynthesizing activities of a lactic acid bacterium for the production of glutamic acid and GABA. The results of this study can be further used for developing functional foods rich inglutamic acid and subsequently GABA as a bioactive compound.

Keywords
γ-amino butyric acid; functional foods; lactic acid bacteria; medium optimization; response surface methodology

 
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