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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 17, No. 1, 2014, pp. 1-5
Bioline Code: ej14001
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 17, No. 1, 2014, pp. 1-5

 en Antibacterial activity of the Antarctic bacterium Janthinobacterium sp. SMN 33.6 against multi-resistant Gram-negative bacteria
Asencio, Geraldine; Lavin, Paris; Alegría, Karen; Domínguez, Mariana; Bello, Helia; González-Rocha, Gerardo & González-Aravena, Marcelo

Abstract

Background: The increment of resistant strains to commonly used antibiotics in clinical practices places in evidence the urgent need to search for new compounds with antibacterial activity. The adaptations that Antarctic microorganisms have developed, due to the extreme environment that they inhabit, promote them as a potential new source of active compounds for the control of microorganisms causing infections associated with health care. The aim of this study was to evaluate the antibacterial activity of an ethanol extract of the Antarctic bacterium Janthinobacterium sp., strain SMN 33.6, against nosocomial multi-resistant Gram-negative bacteria.
Results: Inhibitory activity against human Gram-negative bacterial pathogens, with concentrations that varied between 0.5 and 16 μg ml-1, was demonstrated.
Conclusions: The ethanolic extract of Janthinobacterium sp. SMN 33.6 possesses antibacterial activity against a chromosomal AmpC beta-lactamase-producing strain of Serratia marcescens check for this species in other resources , an extended-spectrum beta-lactamase-producing Escherichia coli check for this species in other resources and also against carbapenemase-producing strains of Acinetobacter baumannii check for this species in other resources and Pseudomonas aeruginosa check for this species in other resources . This becomes a potential and interesting biotechnological tool for the control of bacteria with multi-resistance to commonly used antibiotics.

Keywords
Antarctica; Antimicrobial; Antibiotic resistance; Bacterial pigment

 
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