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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 25, No. 1, 2017, pp. 28-32
Bioline Code: ej17005
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 25, No. 1, 2017, pp. 28-32

 en Radiolytic studies of cefozopran hydrochloride in the solid state
Zalewski, Przemysław; Skibiński, Robert; Szymanowska-Powałowska, Daria; Piotrowska, Hanna; Bednarski, Waldemar & Cielecka-Piontek, Judyta

Abstract

Background: The radiation sterilization is one of the bestmethods for sterilizing vulnerable degradation drugs like cefozopran hydrochloride.
Results: Chemical stability of radiosterylized cefozopran hydrochloride, was confirmed by spectrophotometric and chromatographic methods. EPR studies showed that radiation has created some radical defects whose concentration was no more than several dozen ppm. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy was unaltered for Gram-positive bacteria but changed for two Gram-negative strains. The radiation sterilized cefozopran hydrochloride was not in vitro cytotoxic against human CCD39Lu normal lung fibroblast cell line.
Conclusions: Cefozopran hydrochloride in solid state is not resistant to radiation sterilization and this method cannot be used for sterilization of this compound.

Keywords
Antibacterial prophylaxis; Beta radiation; Cephalosporin; Cytotoxicity; Drug sterilization; Electron paramagnetic resonance spectroscopy; EPR spectra; Ionizing radiation; Microbiological activity; Q-TOF; Radiation sterilization; Thermolabile drugs

 
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