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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 25, No. 1, 2017, pp. 75-83
Bioline Code: ej17013
Full paper language: English
Document type: Research Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 25, No. 1, 2017, pp. 75-83

 en Characterization of Lactobacillus fermentum check for this species in other resources UCO-979C, a probiotic strain with a potent anti- Helicobacter pylori check for this species in other resources activity
García, Apolinaria; Navarro, Karen; Sanhueza, Enrique; Pineda, Susana; Pastene, Edgar; Quezada, Manuel; Henríquez, Karem; Karlyshev, Andrey; Villena, Julio & González, Carlos


Background: Helicobacter pylori check for this species in other resources is considered as the main risk factor in the development of gastric cancer. In the present study, we performed a detailed characterization of the probiotic properties and the anti-H. pylori activity of a previously isolated lactobacillus strain — Lactobacillus fermentum check for this species in other resources UCO-979C — obtained from human gut.
Results: The strain tolerated pH 3.0; grew in the presence of 2% bile salts; produced lactic acid and hydrogen peroxide; aggregated in saline solution; showed high hydrophobicity; showed high adherence to glass; Caco-2 and gastric adenocarcinoma human cells (AGS) cells; showed an efficient colonization in Mongolian Gerbils; and potently inhibited the growth and urease activity of H. pylori strains. L. fermentum UCO-979C significantly inhibited H. pylori-induced IL-8 production in AGS cells and reduced the viability of H. pylori. With regard to innocuousness, the strain UCO-979C was susceptible to several antibiotics and did not produce histamine or beta-haemolysis in blood agar containing red blood cells from various origins.
Conclusion: The results demonstrated that L. fermentum UCO-979C is a very good candidate as a probiotic for the protection of humans against H. pylori infections.

Efficient colonization; Gastric cancer; Highly adherent to glass; Hydrophobic bacteria; Probiotic protection against gastric cancer; Probiotic protection against Helicobacter pylori

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