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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 1, No. 2, 2004, pp. 3-5
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Bioline Code: gm04011
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 1, No. 2, 2004, pp. 3-5
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REVIEW ARTICLE - REMITTING SERONEGATIVE SYMMETRICAL SYNOVITIS WITH PITTING EDEMA (RS3PE) SYNDROME AND MALIGNANCY
Mehmet Sayarlioğlu
Abstract
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a definite subset of the seronegative symmetrical polyarthritis of the aged, characterized by dramatic pitting edema of the hands, male predominance, old age and exquisite response to corticosteroids. RS3PE syndrome is a rare but well-defined syndrome known to be associated with solid tumors and haematologic malignancies. Recent research has shown that it is not a specific entity but rather a syndrome that can represent the inaugural form of various types of rheumatic disease and neoplastic conditions of the elderly. A thorough examination in elderly patients with RS3PE syndrome, and heightened suspicion of potential underlying malignant disease is necessary.
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