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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 1, No. 3, 2004, pp. 12-15
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Bioline Code: gm04025
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 1, No. 3, 2004, pp. 12-15
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COMPARATIVE EFFECTS OF LOSARTAN AND ENALAPRIL ON SERUM DIGOXIN LEVELS IN PATIENTS WITH CONGESTIVE HEART FAILURE
Mustafa Iraz, Zehra Kurcer, Ramazan Özdemir, Aytekin Güven, Alpay Turan Sezgin, Ercüment Ölmez
Abstract
The aim of this study was to investigate the effect of AT1-receptor antagonist, losartan usage in place of angiotensin converting enzyme (ACE) inhibitor, enalapril, in patients with congestive heart failure (CHF) on serum digoxin concentrations. The study was performed in 17 patients (14 men, 3 women) with CHF of New York Heart Association (NYHA) functional class II. Their ages ranged from 42-73 (61.9 ± 2.4) years and they all were being treated with enalapril and digoxin at the time of the study. Serum digoxin levels were measured after 15 days of enalapril treatment just before taking digoxin dose in the morning and 2 and 6 hours after digoxin medication. Then, losartan was added to treatment instead of enalapril and after 15 days, serum digoxin levels were measured again in the same patients. Trough serum digoxin levels were 1.19 ± 0.09 ng/mL after 15 days of enalapril treatment and 1.30 ± 0.13 ng/mL after 15 days of losartan treatment, the digoxin levels at two and six hours after the morning dosage were 1.79 ± 0.18 and 1.43 ± 0.13 ng/mL after enalapril treatment, and 1.88 ± 0.16 and 1.37 ± 0.12 ng/mL after losartan treatment. Losartan treatment did not change the serum digoxin concentrations compared to enalapril treatment. Using losartan instead of enalapril in patients with CHF receiving enalapril together with digoxin did not affect serum digoxin concentrations.
Keywords
Digoxin, enalapril, losartan, pharmacokinetics.
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