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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 1, No. 4, 2004, pp. 29-35
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Bioline Code: gm04041
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 1, No. 4, 2004, pp. 29-35
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SERUM CYSTATIN C: A GOOD MARKER FOR EVALUATION OF GLOMERULAR FILTRATION RATE IN HEPATORENAL SYNDROME
Amgad E. El-Agroudy , Alaa A. Sabry, Hosam A. Ghanem, Ayman El-Baz, Ashraf Fakhry, Hosam M. Gad , Hussein A. Sheashaa , Mohamed Abdel-Hamid, Mahmoud Yousseff, Abd El-Rahman A. Mokhtar
Abstract
To determine if estimation of serum cystatin C could replace creatinine clearance
in routine determinations of glomerular filtration rate (GFR) for early detection
of kidney affection in patients with cirrhosis in a case control study. 40
patients with cirrhosis were included in this study according to Child-Pugh's
classification, 20 patients (group C) and 20 patients (group B). Twenty adults
aged, sex and body mass index matched were used as controls. Serum creatinine
and creatinine clearance were measured by Jaffe reaction. GFR was measured
by 99m Tc-DTPA technique. Serum cystatin C was measured by particle
enhanced immunoturbidimetry. Pearson correlation analyses showed that cystatin
C has no correlation with age or body mass index. Moreover, cystatin C showed
more significant correlation r = -0.85, p <0.001, than serum creatinine r =
-0.32, p <0.05 with GFR measured with 99mTc-DTPA technique in patients
with cirrhosis. The results demonstrated that serum cystatin C values were
significantly higher in hepatorenal syndrome patients than in controls. Results
showed that neither serum creatinine nor creatinine clearance were good indicators
of hepatorenal syndrome(r = 0.089). Serum cystatin C level is independent of
age or body mass index. Thus we suggest that serum cystatin C assay may be
useful marker for early detection of renal insufficiency in hepatorenal syndrome.
Also, the increase in cystatin C is higher in decompansated cirrhotic patients
than in compensated cirrhotic patients.
Keywords
CCystatin-Glomerular Filtration Rate-Hepatorenal syndrome
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