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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 1, No. 4, 2004, pp. 53-64
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Bioline Code: gm04045
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 1, No. 4, 2004, pp. 53-64
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CLINICAL AND ANGIOGRAPHIC RESULTS OF PERCUTANEOUS EXCIMER LASER VERSUS BALLOON ANGIOPLASTY FOR CORONARY INTRA-STENT RESTENOSIS
Aytaç Vural, Igor V. Pershukov, Talantbek A. Batyraliev, Zarema A. Niyazova-Karben, Alexandru Karaus Oleg Calenici, Larisa N. Petrakova,Marina K. Peresypko, Dmitry V. Preobrazhenskii, Boris A. Sidorenko
Abstract
Treatment of in-stent restenosis (ISR) with conventional PTCA causes significant
recurrent neointimal tissue growth in 30-85%. Therefore, laser ablation of
intra-stent neointimal hyperplasia prior to balloon dilatation can be an attractive
alternative. However, the long-term outcomes of such treatment have not been
studied thoroughly enough. This prospective case-control study evaluated angiographic
and clinical outcomes of PTCA alone and a combination of eximer laser coronary
angioplasty (ELCA) and adjunct PTCA in 125 patients with ISR. ELCA was performed
prior to balloon dilatation in 67 patients, PTCA alone was performed in 58
patients. Basic demographic and clinical data were comparable in both groups.
Lesions included in ELCA group were longer (17.1± 9.9 mm versus 13.6±9.1
mm; p=0.034), more complex (36.5% type-C stenoses versus 14.3%; p=0.006) and
more frequently had reduced distal blood flow (TIMI < 3: 18.9% versus 4.8%;
p=0.025) compared to lesions in PTCA group. Immediate angiographic results
of PTCA and ELCA+PTCA appeared to be comparable. PTCA
alone was successful in 57 patients (98.3%), ELCA+PTCA -in 66 patients (98.5%).
The rates of hospital complications were comparable (3.0% in ELCA group versus
8.6% in PTCA group). The 1 year-follow-up showed that the rates of MACE were
comparable in the two groups (37.3% in ELCA group versus 46.6% in PTCA group).
The rates of TVR within 1 year after the intervention were also similar in
ELCA and PTCA groups (32.8% versus 34.5%). The data mean that ELCA in patients
with complex ISR is efficient and safe. Despite a higher complexity of lesions
in ELCA group, no increase in the rate of complications was registered.
Keywords
Eximer laser coronary angioplasty, in-stent restenosis, percutaneous transluminal coronary angioplasty
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