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MECHANISM OF ACTION OF JATROPHA GOSSYPIFOLIA STEM LATEX AS A HAEMOSTATIC AGENT Taofeeq Oduola, Ganiyu Oyebola Adeosun, Tesleem Aderemi Oduola, Godwin Ovie Avwioro, Mutiyat Adeyoola Oyeniyi Abstract Aim: Jatropha gossypifolia belongs to the family "Euphorbiacea". The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy's method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity. Keywords Jatropha gossypifolia, haemostatic agent, mechanism.

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