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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 3, No. 4, 2006, pp. 167-172
Bioline Code: gm06035
Full paper language: English
Document type: Research Article
Document available free of charge

European Journal of General Medicine, Vol. 3, No. 4, 2006, pp. 167-172

 en THE EFFECT OF ANTIOXIDANT CAFFEIC ACID PHENETHYL ESTER (CAPE) ON SOME ENZYME ACTIVITIES IN CISPLATIN-INDUCED NEUROTOXICITY IN RATS
Özyurt, Birsen; Güleç, Mukaddes; Özyurt, Hüseyin; Ekici, Fatih; Atis, Ömer & Akbas, Ali

Abstract

Aim: Neurotoxicity is the next common side effect of cisplatin (CDDP)-based chemotherapeutics following nephrotoxicity. We investigated the effect of CDDP on some brain metabolic enzyme activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) in an experimental model of CDDP toxicity, and examined the protective role of Caffeic acid phenethyl ester (CAPE), a phenolic antioxidant derived from the honeybee propolis, on the enzyme activities mentioned above.
Methods: Female Wistar albino rats were divided into three groups: sham operation group (n:6), CDDP group (n:9), and CAPE + CDDP group (n:8). All the chemicals used were applied intraperitoneally. HK, G6PD, LDH, and MDH activities were determined spectrophotometrically in the brain supernatant at the end of the surgical procedures.
Results: There were decreased G6PD activities and increased MDH activities in CDDP group compared to control group (p<0.05, p<0.05). LDH activities were increased in CAPE+CDDP group compared to CDDP group (p<0.001).
Conclusion: These results provide a new point of view on the glucose metabolizing enzymes of brain tissue affected from CDDP and the protective effects of CAPE on these enzymes.

Keywords
Caffeic acid phenethyl ester, cisplatin, neurotoxicity, metabolic enzymes.

 
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