European Journal of General Medicine
Medical Investigations Society
Vol. 4, No. 4, 2007, pp. 149-153
Bioline Code: gm07036
Full paper language: English
Document type: Research Article
Document available free of charge
European Journal of General Medicine, Vol. 4, No. 4, 2007, pp. 149-153
© Copyright 2007 - Medical Investigations Society
Effects Of Erdosteine On Oxidative-Antioxidative Equilibrium And On Cataract Formation In Rat Pups With Selenite-Induced Cataract|
Kılıç, Adil; Selek, Şahbettin & Erel, Özcan
To investigate whether erdosteine supplementation following selenite exposure affects
oxidant-antioxidant equilibrium and prevents cataract formation in rat pups.
Thirty-nine Wistar-albino rat pups were divided into 3 groups. In Group 1 (n=16)
only s.c saline was injected. In Group 2 (n=10) subcutaneous (s.c.) sodium selenite (30 nmol /
g body weight) was injected on postpartum day 10. In Group 3 (n=13) s.c. sodium selenite (30
nmol/g body weight) were injected on postpartum day 10 and oral erdosteine (10 mg/kg body
weight, daily for one week) was administered by gavage thereafter. The development of cataract
was assessed weekly. The density of cataract was graded by slit-lamp biomicroscopy. On day
21, the blood was collected and lenses were removed. Oxidative stress index (OSI) and total
antioxidant capacity (TAC) were determined in the lenses of the rat pups. Paraoxonase-1 (PON 1)
activity was determined in the sera.
All of the lenses of rat pups in Group 1 remained clean. All rat pups developed dense
nuclear opacity in Group 2. Eight out of 13 rat pups developed slight nuclear opacity in Group 3.
Differences among the groups were statistically significant (p<0.05). Group 2 lenses had higher
mean OSI level than that of Group 3 lenses (p=0.003). Group 2 lenses lower mean TAC levels
than that of Group 3 (not significant). Mean PON 1 level of Group 2 was lower than that of Group
Erdosteine diminishes the incidence of cataract due to its protection of the
antioxidant defense system.
Antioxidant, erdosteine, paraoxonase-1, selenite cataract
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