Diagnostic Value Of CEA, CA-19-9, CA 125 And CA 15-3 Levels In Malignant Pleural Fluids|
Paşaoğlu, Gülden; Zamani, Adil; Can, Gülsüm & İmecik, Oktay
Pleural effusion is a common diagnostic problem. Tumor marker levels in pleural
effusion may be help to distinguish pleural malignancy, but the precise diagnostic value of these
markers remains unclear. The aim of this study was to investigate the diagnostic value of CEA,
CA15-3, CA 19-9 and CA-125.
Pleural fluid and serum levels of these markers were assayed prospectively in 89
patients with pleural effusion (35 malignant and 54 benign) and 25 healthy individuals. The
patients were separated as benign or malignant.
All pleural and serum tumor markers levels were statistically higher in malignant
group than in the benign and control groups. CEA was the marker which had the highest
sensitivity (41.6%), specificity (100%) and accuracy (74.1%). CA 15-3 had also similar
sensitivity, specificity and accuracy (38.8%, 100% and 73.0%, respectively). CA 19-9 and CA
125 sensitivity, specificity and accuracies were lower. CEA+CA 15-3+ CA-125 combination
elevated the diagnostic value to 100% specificity and 78.3% accuracy. The highest diagnostic
value was observed in CA 15-3+CA-125 combination (100% specificity and 80.9% accuracy).
Moreover, pleural CEA and CA 15-3 levels were significantly higher in patients with primary
lung cancer compared to those of patents with extrapulmonary cancer.
In conclusion our results suggest that evaluation of tumor marker combinations
may be useful in order to differentiate malignant pleural fluids.
Tumor marker, CEA, CA 15-3, CA-125, CA 19-9, pleural effusion