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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 4, No. 4, 2007, pp. 176-179
Bioline Code: gm07041
Full paper language: English
Document type: Research Article
Document available free of charge

European Journal of General Medicine, Vol. 4, No. 4, 2007, pp. 176-179

 en Investigation Of Anti-Inflammatory Activity Of Bergamot Oil
Karaca, Mehmet; Özbek, Hanefi; Him, Aydın; Tütüncü, Mehmet; Akkan, Hasan Altan & Kaplanoğlu, Veysel

Abstract

Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test.
Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent.
Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg.
Conclusion: The results showed that BO posseses promising anti-inflammatory effect.

Keywords
Citrus aurantium subsp. bergamia, Bergamot oil, anti-inflammatory activity, carrageenan-oedema.

 
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