European Journal of General Medicine
Medical Investigations Society
Vol. 4, No. 4, 2007, pp. 176-179
Bioline Code: gm07041
Full paper language: English
Document type: Research Article
Document available free of charge
European Journal of General Medicine, Vol. 4, No. 4, 2007, pp. 176-179
© Copyright 2007 - Medical Investigations Society
Investigation Of Anti-Inflammatory Activity Of Bergamot Oil|
Karaca, Mehmet; Özbek, Hanefi; Him, Aydın; Tütüncü, Mehmet; Akkan, Hasan Altan & Kaplanoğlu, Veysel
Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using
carrageenan-induced rat paw oedema test.
For the anti-inflammatory activity measurement six different groups were established
and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was
used as a reference agent.
It was found that reduction in the inflammation was 95.70% with indomethacin,
27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO.
Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The
strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective
dose (ED50) value of BO was found to be 0.079 mL/kg.
The results showed that BO posseses promising anti-inflammatory effect.
Citrus aurantium subsp. bergamia, Bergamot oil, anti-inflammatory activity, carrageenan-oedema.
Alternative site location: http://www.ejgm.org