European Journal of General Medicine
Medical Investigations Society
Vol. 4, No. 4, 2007, pp. 186-189
Bioline Code: gm07043
Full paper language: English
Document type: Research Article
Document available free of charge
European Journal of General Medicine, Vol. 4, No. 4, 2007, pp. 186-189
© Copyright 2007 - Medical Investigations Society
Hyperbaric Oxygen Therapy In Calcium Chloride Extravasation Injuries: An Experimental Animal Study|
Aydınöz, Seçil; Süleymanoğlu, Selami; Haholu, Aptullah; Uzun, Günalp; Karademir, Ferhan; Yıldız, Şenol & Göçmen, İsmail
Parenteral alimentation fluids containing calcium are widely used to treat sick neonates
and children. Extravasation of calcium presents with local swelling, erythema, blistering and
progresses to skin necrosis and skin loss. Several treatment modalities including hyperbaric
oxygen therapy have been used for extravasation injuries. The role of hyperbaric oxygen therapy
on extravasation injuries was investigated in this study by an experimental rat model based on
facilitating effect of hyperbaric oxygen on wound healing.
After shaving the dorsal side of 16 female Wistar rats, 1 ml of calcium chloride were
injected intradermally. The rats were divided into two groups as control and hyperbaric oxygen.
The control group received no treatment while the hyperbaric oxygen group received hyperbaric
oxygen therapy for 7 days after injection. At the end of seventh day skin biopsy including all
necrotic tissue and surrounding healthy tissue were obtained and histopathologic examination
was performed for control and hyperbaric oxygen groups.
Hyperbaric oxygen group showed a statistically significant preservation of epidermis
and dermis with minimal necrosing findings of skin injury.
Although further research is required to develop management guidelines, we
concluded that in this experimental study, hyperbaric oxygen therapy prevents dermal injury and
may decrease the morbidity associated with calcium chloride extravasation injury.
Extravasation injury, calcium, skin loss
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