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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 6, No. 1, 2009, pp. 1-5
Bioline Code: gm09001
Full paper language: English
Document type: Research Article
Document available free of charge

European Journal of General Medicine, Vol. 6, No. 1, 2009, pp. 1-5

 en The Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitro
Ölçer, Havva Feyza; Erol, Atilla; Şahin, Ayşe S & Otelcioğlu, Şeref

Abstract

Aim: The purpose of this study was to determine the mechanism of the directs effects of sevoflurane on human veins in vitro.
Methods: Dose-response curves were obtained for cumulative doses of sevoflurane (0.5, 1, 1.5 and 2 MAC) on saphenous vein strips precontracted with 5-hydroxytryptamine ( 5-HT 10-6 mol/L) incubated with either Nω-nitroL-arginine-methyl ester (L-NAME) (10-4 mol/L), indomethacine (10-5 mol/L), glibenclamide (10-6 mol/L) or tetraethylammonium (10-4 mol/L)
Results: Preincubation of vein strips with tetraethylammonium (TEA, Ca++-activated K+ channel blocker) did not influence the relaxant responses to sevoflurane (p>0.05). L-NAME, indomethacine and glibenclamide reduced the relaxation response to sevoflurane (p<0.05).
Conclusion: Our results demonstrated that sevoflurane produces concentration dependent relaxation in human saphenous vein. The relaxant effects of sevoflurane are probably related with activation of nitric oxide synthase, cyclooxygenase and KATP channels pathways.

Keywords
Sevoflurane, vascular effect, saphenous vein, in vitro

 
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