search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 6, No. 3, 2009, pp. 170-174
Bioline Code: gm09037
Full paper language: English
Document type: Research Article
Document available free of charge

European Journal of General Medicine, Vol. 6, No. 3, 2009, pp. 170-174

 en Immuno-haematological characteristics of Nigerian sickle cell disease patients in asymptomatic steady state
Salawu, L.; Orimolade, E. A. & Durosinmi, M. A.

Abstract

Aim: The aim of this study is to investigate some immuno-haematological characteristics of Nigerian sickle cell disease (SCD) patients in asymptomatic steady state.

Material and Methods: Thirty asymptomatic SCD patients and 30 apparently healthy age- and sex-matched non-sickle cell dis-ease individuals were investigated. The packed cell volume, white blood cells and differentials, and platelet counts were done on automated blood cells counter, while the ESR was determined by Westergren′s technique. C3 activator, C1-INH, IgA, IgG and IgM were estimated by the single radial immuno-diffusion method.

Results: The SCD patients had elevated ESR and a significantly higher total leukocyte count compared to the controls (t= 5.22, p= 0.000). A positive correlation was found between ESR and C3 activator (r= +0.449, p= 0.047), and between ESR and serum IgM levels (r= +0.531, p= 0.016). Serum levels of IgA and C3 activator were significantly higher in SCD subjects (IgA: t= 2.47, p= 0.019; C3 activator: t= 2.79, p= 0.009), while the levels of C1-INH and 1gM, though higher in SCD subjects, were not significant.

Conclusions: It could be concluded from this study that immune dysfunction are evident in Nigerian SCD patients.

Keywords
Immuno-haematological parameters, sickle cell disease, asymptomatic steady state, Nigeria

 
© Copyright 2009 European Journal of General Medicine.
Alternative site location: http://www.ejgm.org

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2019, Site last up-dated on 11-Sep-2019.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil