Hiccup is a spasmodic, involuntary contraction of the inspiratory muscles, associated with delayed, abrupt glottic closure, causing a peculiar sound. There are numerous causes of hiccup, includ-ing diseases of the gastrointestinal tract. Hiccup is reported to represent an atypical manifestation of the gastroesophageal reflux disease (GERD).
We report two cases with hiccup due to GERD. Endoscopic exami-nations showed esophagitis, Los Angeles class grade A and B, in two cases whose hiccups were improved by proton pump inhibitors (PPI).
Hiccup is atypical symptom of GERD. If hiccup is due to GERD, then it may be improved with ppi therapy.
