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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 7, No. 1, 2010, pp. 92-93
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Bioline Code: gm10014
Full paper language: English
Document type: Case Report
Document available free of charge
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European Journal of General Medicine, Vol. 7, No. 1, 2010, pp. 92-93
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Hepatitis B reactivation with fulminant hepatitis during rituximab chemotherapy in a patient with follicular lymphoma
Acar, Kadir; Göktepe, Mevlüt; Polat, İlker & Atalay, Hüseyin
Abstract
A 52-year-old man was diagnosed Follicular lymphoma with autoimmune hemolytic anemia. At time of diagnosis his HBs Ag was (+), Anti-HBs (-), and HBV DNA was negative. Chemotherapy was interrupted after tree cycles of R-CVP due to elevated liver enzyme. At that time HBV DNA became positive. Lamivudine therapy was started, whereas patient died due to fulminant hepatic failure. The high morbidity and mortality of this complication is one of the major obstacles to completing the standard treatment for lymphoma in HBV carriers. Thus, preventive therapy with nucleoside or nucleotide analogs should be started before the chemotherapy to prevent HBV reactivation.
Keywords
Hepatitis B reactivation, lymphoma, lamuvudine, rituximab
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© Copyright 2010 European Journal of General Medicine. Alternative site location: http://www.ejgm.org
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