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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 7, No. 2, 2010, pp. 187-191
Bioline Code: gm10028
Full paper language: English
Document type: Research Article
Document available free of charge

European Journal of General Medicine, Vol. 7, No. 2, 2010, pp. 187-191

 en The Association Between Polymorphism of Lys198Asn of Endothelin-1 Gene and Arterial Hypertension Risk in Kazakh People
Dzholdasbekova, A.U. & Gaipov, A.E.


Aim: We researched frequency distribution of genotypes and alleles Lys198Asn of polymorphism of endothelin -1 gene associated with arterial hypertension development in Kazakh people
Method: The research included 120 patients suffering arterial hypertension of 2-3 degree, average, high and very high degree of risk, and control group included 80 actually healthy person of Kazakh nationality.
Result: The research discovered that development of arterial hypertension in the present ethnic group associated with polymorphism of endothelin-1 gene.
Conclusion: At that, allele 198Asn and AsnAsn genotype of endothelin-1 gene act as marker of increased risk of arterial hypertension development.

Genes, endothelin, hypertension, genetic, blood pressure

© Copyright 2010 European Journal of General Medicine.
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