Case Report - Fluorescence in Situ Hybridization Analysis of Balanced t (8;22) (q24.3;q12.2) in a Female with Recurrent Spontaneous Abortions

Genetic counselling of couples with recurrent spontaneous abortions is among the most difficult areas in reproductive medicine. A large number of possible contributing factors responsible for recurrent miscarriages have been identified in recent years (Kumar, et al.1999). Participation of genetically imbalanced gametes in the process of fertilisation is a well recognised cause of recurrent spontaneous abortions. The imbalance may be familial or de novo and can be detected through the cytogenetic study of abortuses. Unbalanced gametes may also arise during meiosis when a balanced chromosome rearrangement is carried out by one of two apparently healthy parents. We report a balanced reciprocal translocation in a women with recurrent spontaneous abortions.