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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 9, No. 1, 2003, pp. 10-12
Bioline Code: hg03003
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 9, No. 1, 2003, pp. 10-12

 en Chromosomal Instability in peripheral blood lymphocytes in patients with malignancy
Tulika Bose


There are lot of studies on the cytogenetic changes in solid tumours but there are very few studies on the cytogenetic changes in peripheral blood by mphosytes in patients with malignancy.

In the present study we evaluated peripheral blood lymphocyte cytogenetic changes on short term culture. Twenty four out of 250 patients with various malignancies showed some aberration of karyotypes in peripheral lymphocytes (9-6%) suggesting an underlying genetic instability in these cancer patients or alternatively demonstrating that these changes could be related to exposure to environmental mutagens.

Chromosomal immutability, Cancer cytogenetics, Acrocentric association, Anenploidy, Peripheral blood lymphocytes

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