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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 10, No. 2, 2004, pp. 73-75
Bioline Code: hg04016
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 10, No. 2, 2004, pp. 73-75

 en Mitotic index in Down syndrome - Is it an indicator of immunological status
Ranganath Priya, Suresh Geetha, Subramaniam Amudha, Rajangam Sayee


Down syndrome (DS) is a condition in which the genes on chromosome 21 occur in three copies. This is supposed to influence the growth in the tissues of the body and this could lead to a decreased mitotic index. In view of this, the present investigation was carried out using peripheral lymphocyte culture to find out whether there is a change in mitotic index in DS patients. Mitotic index in male and female patients was reduced to an average of 3.64 and 3.82 respectively. Thus, the index could be an indicator of the reduced immunological status of the individual with DS.

Mitotic index, immunology in Down syndrome

© Copyright 2004 Indian Journal of Human Genetics.
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