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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 11, No. 1, 2005, pp. 44-46
Bioline Code: hg05008
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 11, No. 1, 2005, pp. 44-46

 en Case Report - Nucleolar organising region evaluation using new NOR FISH probe
Rao Babu V., Ghosh K., Mohanty D.


We have carried out chromosomal analysis in a couple with repeated spontaneous abortions (RSA). The chromosomal analysis of male revealed 15ps+ and the chromosome 15 appeared as submetacentric, C- group chromosome. First time we have attempted fluorescence in situ hybridization (FISH) using NOR probe (dJ1174 A5) and FISH analysis revealed NOR duplication on chromosome 15 which was also quantitated using Q-FISH software. The identical NOR duplication also detected in chromosome preparations from products of conception. However, NOR studies in large group of patients is necessary to understand the role of NORs in RSA.

NOR duplication, addition on chromosome 15, repeated spontaneous abortions, NOR variation, FISH NOR

© Copyright 2005 Indian Journal of Human Genetics.
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