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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 11, No. 2, 2005, pp. 94-98
Bioline Code: hg05021
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 11, No. 2, 2005, pp. 94-98

 en Cytogenetic causes for recurrent spontaneous abortions - An experience of 742 couples (1484 cases)
Dubey S, Chowdhury MR, Prahlad B, Kumar V, Mathur R, Hamilton S, Kabra M, Menon PSN, Verma IC


BACKGROUND: First trimester pregnancy loss is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important cause of recurrent pregnancy loss particularly in the first trimester.
AIMS: In this study an evaluation of the contribution of chromosomal anomalies in causing repeated spontaneous abortions was made.
METHODS AND MATERIALS: A review of the cytogenetic data in 742 couples (1484 individuals) with recurrent spontaneous abortions who were examined for chromosomal aberrations in the period 1990-2003 is presented. Women who had at least two abortions, or spontaneous abortions preceded or followed by fetal deaths or birth of a malformed child, and patients who had recurrent spontaneous abortions (> 3) with normal live issue/s were studied.
RESULTS: Chromosomal rearrangements were found in 31 individuals (2%). These abnormalities included 22 (2.9%) structural aberrations, 9 (1.2%) numerical anomalies. In addition to these abnormalities, 21 (3.2%) chromosomal variants were also found.
CONCLUSION: Chromosomal analysis is an important etiological investigation in couples with repeated spontaneous abortions as it helps in genetic counseling and deciding about further reproductive options.

Chromosomal abnormalities; reciprocal translocation; recurrent spontaneous abortion; Robertsonian translocation

© Copyright 2005 Indian Journal of Human Genetics.
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