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Case Report - Lissencephaly child showing FISH negative and mutation in DCX gene with normal parental genetic makeup Gupta BhushanV, Verma Sohani, Raina VP, Iravathy GoudK Abstract Lissencephaly is a clinically and genetically heterogeneous malformation of the brain, leading to a severe disabling condition and seizures. The recent discovery of molecular techniques and identification of lissencephaly genes (LIS 1 and DCX) has allowed etiologic diagnosis of this disorder. We describe a patient with lissencephaly in whom fluorescence in situ hybridization and DCX mutation analysis determined etiologic diagnosis, allowing precise genetic counseling and providing prenatal diagnosis for the family. Keywords DCX gene mutation, lissencephaly, Miller-Dieker syndrome, smooth brain

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