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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 14, No. 3, 2008, pp. 77-81
Bioline Code: hg08018
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 14, No. 3, 2008, pp. 77-81

 en Fc gamma receptor polymorphisms in systemic lupus erythematosus and their correlation with the clinical severity of the disease
Pradhan, Vandana; Patwardhan, Manisha & Ghosh, K


Receptors for the Fc domains of IgG (Fc γ R) play a critical role in linking humoral and cellular immune responses. The various Fc γ R genes may contribute to differences in infectious and immune related diseases in various ethnic populations. Polymorphisms of Fc γ R mainly Fc γ R IIA, IIB, IIIA, IIIB have been identified as genetic factors influencing susceptibility to disease or disease course of a prototype autoimmune disease like Systemic Lupus Erythematosus (SLE). Activated and inhibitory Fc γ Rs seem to play an important role in the pathogenesis of SLE, in initiation of autoimmunity, the subsequent development of inflammatory lesions and finally immune clearance mechanisms. This review focuses on the role of Fc γ R polymorphism and their association with clinical manifestations and initiation of autoantibody production, inflammatory handling of immune complexes and disease development in SLE patients.

Systemic Lupus Erythematosus (SLE), Fc gamma receptors (Fc γ Rs), IgG, Fc γ RIIA, Fc γ R IIB, Fc γ R IIIA, Fc γ R IIIB.

© Copyright 2008 Indian Journal of Human Genetics.
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