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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 1998-362x
Vol. 15, No. 1, 2009, pp. 3-8
Bioline Code: hg09002
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 15, No. 1, 2009, pp. 3-8

 en Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy
Chakraborty, Nitya G

Abstract

Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important.

Keywords
Tumor antigens, Cytotoxic T Lymphocyte (CTL) Regulatory T cells (Tregs), Interleukin-10 (IL-10)

 
© Copyright 2009 Indian Journal of Human Genetics.
Alternative site location: http://www.ijhg.com/

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