Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
Vol. 15, No. 1, 2009, pp. 9-12
Bioline Code: hg09003
Full paper language: English
Document type: Research Article
Document available free of charge
Indian Journal of Human Genetics, Vol. 15, No. 1, 2009, pp. 9-12
© Copyright 2009 Indian Journal of Human Genetics.
Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran|
Galehdari, Hamid; Foroughmand, Ali Mohammad; Soorki, Maryam Naderi & Mohammadian, Gholamreza
Background : The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins.
Materials and Methods : We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.
Result : None of the analyzed samples revealed deafness-associated mutation.
Conclusion : This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness.
Connexin 26, GJB2, Iranian Arabs, nonsyndromic autosomal recessive deafness
Alternative site location: http://www.ijhg.com/