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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 15, No. 2, 2009, pp. 49-53
Bioline Code: hg09013
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 15, No. 2, 2009, pp. 49-53

 en High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene
Patkar, Sushma; Charita, B H; Ramesh, C & Padma, T


In this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed significantly high risk of essential hypertension for individuals who were obese, with a positive family history and with non-vegetarian food habits. Though the intron 4b/a polymorphism of eNOS gene did not reveal any association with essential hypertension in general, males with a/a genotype of the polymorphism did show significantly high risk for developing hypertension.

Essential hypertension, endothelial NOS gene, polymorphism

© Copyright 2009 Indian Journal of Human Genetics.
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