About Bioline  All Journals  Testimonials  Membership  News

Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 16, No. 3, 2010, pp. 119-126
Bioline Code: hg10026
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 16, No. 3, 2010, pp. 119-126

 en Bone age is the best predictor of growth response to recombinant human growth hormone in Turner's syndrome
Ismail, Nagwa Abdallah; Metwaly, Nermeen Salah Eldin; El-Moguy, Fatma Ahmed; Hafez, Mona Hassan; Abd El Dayem, Soha M. & Farid, Tarek Mohamed


Background and Objectives: Recombinant human growth hormone (rhGH) is approved for use in children with Turner′s syndrome (TS) in most industrialized countries and is recommended in the recently issued guidelines. We determined the growth responses of girls who are treated with rhGH for TS, with an aim to identify the predictors of growth response.
Materials and Methods: Fifty-six prepubertal girls with TS, documented by peripheral blood karyotype, were enrolled. All the patients received biosynthetic growth hormone therapy with a standard dose of 30 IU/m 2 /week. The calculated dose per week was divided for 6 days and given subcutaneously at night.
Results: This study showed that rhGH therapy provides satisfactory auxological results. Bone age delay is to be considered as a predictive factor which may negatively influence the effect of rhGH therapy on final height. The growth velocity in the preceding year is the most important predictor of rhGH therapy response.
Conclusion: These observations help us to guide rhGH prescription, to reduce the risks and costs.

Bone age, growth hormone therapy, Turner′s syndrome

© Copyright 2010 Indian Journal of Human Genetics.
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil