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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 17, No. 2, 2011, pp. 90-93
Bioline Code: hg11021
Full paper language: English
Document type: Book Review
Document available free of charge

Indian Journal of Human Genetics, Vol. 17, No. 2, 2011, pp. 90-93

 en G-C heterozygosis in mutS homolog2 as a risk factor to hereditary nonpolyposis colon cancer in the absence of a family medical history
Arvayo-Zatarain, Jorge Alfonso.; Grijalva-Chon, José Manuel.; Castro-Longoria, Reina & Varela-Romero, Alejandro


To detect the presence of point mutations in a small section of the mutS homolog2 (MSH2) gene in both healthy and affected persons treated at the General Hospital of the State of Sonora, a 353 base pair section of the MSH2 gene was amplified and sequenced from six persons affected by hereditary nonpolyposis colorectal cancer and from 19 healthy persons. The affected persons did not show the mutations reported in the scientific literature; however, six healthy persons were heterozygote and mutant-allele carriers. The heterozygote condition implies that carriers are candidates for the development of colorectal cancer. However, it is important to know the family medical history when investigating hereditary mutations.

Colorectal cancer, hereditary nonpolyposis colon cancer, mutS homolog 2 gene, point mutation

© Copyright 2011 Indian Journal of Human Genetics.
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