Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
Vol. 18, No. 1, 2012, pp. 109-111
Bioline Code: hg12020
Full paper language: English
Document type: Report
Document available free of charge
Indian Journal of Human Genetics, Vol. 18, No. 1, 2012, pp. 109-111
© Copyright 2012 Indian Journal of Human Genetics.
Recombination in human leukocyte antigen region in two Asian Indian families|
Mishra, Mahendra N. & Sharma, Ajay
Background: Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles.
Settings and Design: A prospective study at a tertiary care centre.
Aim : To report two rare cases of crossing over in HLA region.
Materials and Methods: Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples.
Results: In one patient crossing over had taken place in the region of A locus resulting in inheritance of AFNx0101 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10.
Conclusions: Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.
AML, human leukocyte antigen, recombination, sequence specific primers
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