Arsenic Exposure from Drinking-water and Carotid Artery Intima-medial Thickness in Healthy Young Adults in Bangladesh

Epidemiological studies have linked high levels (>200 μg/L) of chronic exposure to arsenic in drinking-water with elevated risks of several vascular diseases. In this pilot study, the association between low-level arsenic exposure and carotid artery intimal-medial thickness (IMT) was evaluated among 66 healthy, normotensive, relatively young individuals (mean age 35 years) participating in the ongoing Health Effects of Arsenic Longitudinal Study in Bangladesh. Participants with a higher carotid IMT (>0.75 mm) in general had higher levels of past chronic exposure of arsenic than those with a lower carotid IMT (≤0.75 mm). Although the differences in average arsenic exposure between the two groups were not statistically significant, the findings suggest a possible association between low-level arsenic exposure from drinking-water and carotid atherosclerosis, warranting the need for larger studies.

Keywords
Arsenic; Arsenic exposure; Carotid arteries; Atherosclerosis; Drinking-water; Bangladesh