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The Journal of Health, Population and Nutrition
ISSN: 1606-0997
EISSN: 1606-0997
Vol. 26, No. 4, 2008, pp. 388-396
Bioline Code: hn08040
Full paper language: English
Document type: Research Article
Document available free of charge

The Journal of Health, Population and Nutrition, Vol. 26, No. 4, 2008, pp. 388-396

 en Economic Impact of a Rotavirus Vaccine in Brazil
Constenla, D.O.; Linhares, A.C.; Rheingans, R.D.; Antil, L.R.; Waldman, E.A. & Da Silva, L.J


The study was done to evaluate the cost-effectiveness of a national rotavirus vaccination programme in Brazilian children from the healthcare system perspective. A hypothetical annual birth-cohort was followed for a five-year period. Published and national administrative data were incorporated into a model to quantify the consequences of vaccination versus no vaccination. Main outcome measures included the reduction in disease burden, lives saved, and disability-adjusted life-years (DALYs) averted. A rotavirus vaccinationprogramme in Brazil would prevent an estimated 1,804 deaths associated with gastroenteritis due to rotavirus, 91,127 hospitalizations, and 550,198 outpatient visits. Vaccination is likely to reduce 76% of the overall healthcare burden of rotavirus-associated gastroenteritis in Brazil. At a vaccine price of US$ 7-8 per dose, the cost-effectiveness ratio would be US$ 643 per DALY averted. Rotavirus vaccination can reduce the burden of gastroenteritis due to rotavirus at a reasonable cost-effectiveness ratio.

Costs and cost analysis; Diarrhoea, Infantile; Gastroenteritis; Morbidity; Rotavirus; Rotavirus vaccines; Vaccination; Brazil

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