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The Journal of Health, Population and Nutrition
ISSN: 1606-0997
EISSN: 1606-0997
Vol. 28, No. 1, 2010, pp. 7-13
Bioline Code: hn10002
Full paper language: English
Document type: Research Article
Document available free of charge

The Journal of Health, Population and Nutrition, Vol. 28, No. 1, 2010, pp. 7-13

 en Drug-susceptibility Patterns of Mycobacterium tuberculosis check for this species in other resources in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen
Green, E.; Obi, C.L.; Nchabeleng, M.; de Villiers, B.E.; Sein, P.P.; Letsoalo, T.; Hoosen, A.A.; Bessong, P.O. & Ndip, R.N.


Multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. The prevalence of drug resistance in Mycobacterium tuberculosis check for this species in other resources (MTB) isolates (n=692) from Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from 6.7% for three drugs to 34% for four drugs, with significant predictors being patients’ age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be done for every case.

Drug resistance, Microbial; Mycobacterium tuberculosis; Risk factors; Tuberculosis; South Africa

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