The Journal of Health, Population and Nutrition
Vol. 28, No. 3, 2010, pp. 230-237
Bioline Code: hn10030
Full paper language: English
Document type: Research Article
Document available free of charge
The Journal of Health, Population and Nutrition, Vol. 28, No. 3, 2010, pp. 230-237
© Copyright 2010 Journal of Health Population and Nutrition.
Low-dose β-carotene Supplementation and Deworming Improve Serum Vitamin A and β-carotene Concentrations in Preschool Children of Bangladesh|
Haque, Rashidul; Ahmed, Tanvir; Wahed, M. A.; Mondal, Dinesh; Hamidur Rahman, A. S. M.. & Albert, John M.
Despite the national vitamin A and antihelminthic prophylaxis programmes, both intestinal geohelminths and subclinical vitamin A deficiency continue to be
prevalent among children in developing countries. Studies on potential synergistic effects of vitamin A supplementation and deworming on retinol status have inconsistent results.
The purpose of the present study was to investigate the impacts of low-dose β-carotene supplementation and antihelminthic therapy on serum retinol and β-carotene
concentrations in preschool children of Bangladesh. Two hundred and forty-four children, known to be infected with As-caris lumbricoides, were randomized into four
treatment groups: I-IV. Group I and II received two oral doses of 400 mg of albendazole each, the first dose at baseline and the second dose after four months; Group III
and IV received placebo in place of albendazole. In addition, Group I and III received 1.2 mg of β-carotene powder in capsule daily for six months, and Group II and
IV received placebo in place of β-carotene. Se-rum retinol and β-carotene levels were measured before and after six months of the interventions. Serum retinol
and β-carotene increased significantly in Group I where both antihelminthic therapy and daily β-carotene supplementation were given (p<0.05 and p<0.001
respectively). Antihelminthic therapy alone only improved serum β-carotene concentration (p<0.0001). Low-dose β-carotene supplementation, along with an
antihelminthic therapy, synergistically improved vitamin A status. This finding has public-health implications for improving vitamin A status of children in developing
Albendazole; Antihelminthics; Ascariasis; Ascaris lumbricoides;β-carotene; Children; Deworm-ing; Impact studies; Retinol; Vitamin A deficiency; Bangladesh
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