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The Journal of Health, Population and Nutrition
icddr,b
ISSN: 1606-0997
EISSN: 2072-1315
Vol. 28, No. 5, 2010, pp. 443-449
Bioline Code: hn10058
Full paper language: English
Document type: Research Article
Document available free of charge

The Journal of Health, Population and Nutrition, Vol. 28, No. 5, 2010, pp. 443-449

 en Monitoring antimicrobial susceptibility of Neisseria gonorrhoeae check for this species in other resources isolated from Bangladesh during 1997- 2006: Emergence and pattern of drug-resistant isolates
Ahmed, Monir Uddin; Hasan Chawdhury, Faisal Arif; Hossain, Maqsud; Sultan, Syed Zafar; Alam, Mansur; Salahuddin, Gazi; Alam, Ashraful; Nessa, Khairun; Nahar, Shamsun; Shama-A-Waris; Alam, Anadil & Rahman, Motiur

Abstract

Gonorrhoea is one of the most common sexually transmitted infections (STIs) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae check for this species in other resources is a major obstacle in the control of gonorrhoea. Periodical monitoring of antimicrobial susceptibility of N. gonorrhoeae is essential for the early detection of emergence of drug resistance. In total, 1, 767 gonococcal strains isolated from males and females (general population and those with high-risk behaviour) from different parts of Bangla-desh were studied during 1997- 2006 . Minimum inhibitory concentrations of penicillin, tetracycline, cipro-floxacin, ceftriaxone, spectinomycin, and azithromycin for the isolates were determined by the agar dilu-tion method. Isolates resistant to three or more antimicrobial agents are considered multidrug-resistant. The prevalence of plasmid-mediated penicillinase-producing N. gonorrhoeae (PPNG) and plasmid-mediated tetracycline-resistant N. gonorrhoeae (TRNG) was determined. Nine percent of the isolates were resistant to ciprofloxacin in 1997 compared to 87% in 2006. Multidrug-resistant N. gonorrhoeae have emerged in 1997 , and 44% of the strains (n= 66) isolated during 2006 were multidrug-resistant. Forty-two percent of the isolates in 2006 were both PPNG- and TRNG-positive compared to none in 1997 . The rapidly-changing pattern of gonococcal antimicrobial susceptibility warrants the need for an antimicrobial susceptibility-monitoring programme, and periodical analysis and dissemination of susceptibility data are essential to guide clinicians and for successful STI/HIV intervention programmes.

Keywords
Drug resistance, Microbial; Gonorrhoea; Neisseria gonorrhoeae; Sexually transmitted infections; Surveillance; Bangladesh

 
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