The Journal of Health, Population and Nutrition
Vol. 33, No. 2, 2015, pp. 1-9
Bioline Code: hn15040
Full paper language: English
Document type: Literature Review
Document available free of charge
The Journal of Health, Population and Nutrition, Vol. 33, No. 2, 2015, pp. 1-9
© Copyright 2015 - The Journal of Health, Population and Nutrition
Do fatty acids affect fetal programming?|
Kabaran, Seray & Besler, H. Tanju
Background: In this study discussed the primary and regulatory roles of fatty acids, and investigated the affects of fatty
acids on metabolic programming.
Methods: Review of the literature was carried out on three electronic databases to assess the roles of fatty acids in
metabolic programming. All abstracts and full-text articles were examined, and the most relevant articles were selected
for screening and inclusion in this review.
Results: The mother’s nutritional environment during fetal period has important effects on long term health. Fatty acids
play a primary role in growth and development. Alterations in fatty acid intake in the fetal period may increase the risk
of obesity and metabolic disorders in later life. Maternal fatty acid intakes during pregnancy and lactation are passed to
the fetus and the newborn via the placenta and breast milk, respectively. Imbalances in fatty acid intake during the fetal
period change the fatty acid composition of membrane phospholipids, which can cause structural and functional
problems in cells. Additionally, the metabolic and neuroendocrine environments of the fetus and the newborn play key
roles in the regulation of energy balance.
Conclusions: Imbalances in fatty acid intake during pregnancy and lactation may result in permanent changes in
appetite control, neuroendocrine function and energy metabolism in the fetus, leading to metabolic programming.
Further studies are needed to determine the role of fatty acid intake in metabolic programming.
Fatty acids; Fetal programming; Maternal nutrition
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